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Freeze Drying in the laboratory

Buchi is the market leader in laboratory evaporation, BUCHI offers the first laboratory Freeze Dryer with Infinite-Technology™ and Infinite-Control™. Applications range from research and development to quality control within a broad spectrum of market segments. Our BUCHI solutions stand out by their efficiency and practical capability.

l 300 1Lyovapor™ L-300

With Infinite-Technology™ the Lyovapor™ L-300 offers continuous sublimation for the first time with two alternately working and automatically hygienically cleansed condensers at -105 °C. In addition, Infinite-Control™ allows entire process control of all relevant parameters, also via mobile devices.

l 200 1Lyovapor™ L-200

The compact Lyovapor™ L-200 offers high-quality Freeze Drying (-55 °C, 6 kg) with a high level of automation. Infinite-Control™ includes easy method creation, method running, data logging, chart recording in real-time and interruption if needed from anywhere at anytime.

Webinar: Freeze Drying Optimization

Simple tools and tips to improve freeze drying efficiency

Application Tips

hot way

A pretty hot way to speed up the freeze drying process

If you use a shelf freeze dryer and want to perform your lyophilization faster, then this post might pique your interest. Here I describe a common accessory for quickening the lyophilization process, mainly heated shelves. I also point out important considerations for using heatable shelves and give advice on how to avoid destroying your product while aiming for maximal speed. 

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manifold freeze

Shall we use shell freezing to speed up manifold freeze drying?

If you are looking for ways to perform manifold freeze drying faster, then you’ve landed in the right place. In this post, I briefly discuss the main factors that affect drying rates during lyophilization. Then I point out how shell freezing can bring you substantial time saving benefits compared to bulk freezing and offer a few examples to illustrate my point. Spend a few minutes here, to discover how you can shave many minutes off your own workflow. 

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Why pressure gradients are the main drivers in improving sublimation rates

From ski slopes to marble race tracks, a good height gradient is an absolute must to generate speed. Your freeze dryer is no different, but it appreciates temperature and pressure gradients rather than height gradients. Contrary to common belief, very low-pressure values might be hurting the rate of the freeze-drying process, rather than improving it. Instead, use this post to learn how pressure gradients can increase lyophilization speed. 

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appli pressure endpoint

How to find a suitable pressure endpoint criterion for freeze drying

Ending the primary and secondary drying step at the right moment is a key aspect to improving the efficiency of your freeze-drying process. Using pressure as an endpoint criterion is a great approach for determining the endpoint of these two lyophilization steps. Read on as I describe the tools you need for comparative pressure measurement. I also show you some experimental data that could come in handy when you try to establish the most suitable endpoint criterion for your applications.

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